Detroit and Buffalo both arrive 1-0 for one of the strongest matchups on the Week 2 board.
NFL Research notes the Bills and Lions are tied for the most regular-season wins over the last 50 games, with 36 each. Buffalo’s new stadium adds another layer to the Thursday-night opener.
FanDuel’s current board lists Buffalo -4.5 with a 54.5 total. Sports4Play has Bills -4.5 as a tracked selection.
Both teams scored at least 30 in Week 1, making offensive efficiency, red-zone execution and late-game possessions central to the matchup.